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Coronavirus

Make your mark by uncovering groundbreaking insights into the transmission, progression, and treatment of coronaviruses.

Developing animal models that reproduce human pathogenesis conditions accurately is challenging. A recent study describes the use of the DSI Buxco Finepointe Inhalation Tower which allowed exposure of anaesthetized mice to aerosolized virus under controlled conditions and the FinePointe Whole Body Plethysmography system for assessing respiratory parameters.

From animal model development to disease progression investigation, DSI has you covered.

Know the delivered dose!

Did you know every animal has a unique breathing pattern that, if not accounted for, could lead to inconsistencies in your inhalation study data?

Check out the video above for a video demonstration of the Accumulated Inhaled Aerosol (AIA) parameter, available exclusively in DSI's Buxco FinePointe software!







Increasing world populations and ease of international travel are driving the necessity for better preparedness to protect the public from infectious disease outbreaks, as is evident with the coronavirus outbreak of 2019 and 2020.  The scientific community works tirelessly to identify prevention and treatment options, but are chasing a villain that changes form as the virus mutates.  Research to identify virus-specific and universal vaccines as well as effective treatments is on-going.  

Whether you need to create an animal model of coronavirus, are studying disease progression, or are testing new treatments, DSI has solutions to get you the high-quality data required to make meaningful conclusions.

Did you know that we work with many of the BSL-3 and -4 labs throughout the United States? Check out this video from NBC News highlighting the hard work these labs are putting in to combat COVID-19.
coronavirus, MERS, SARS, Covid-19









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Animal Model Development
Inhalation Solutions
Need to create an animal model of disease or test a treatment compound? Our inhalation exposure solutions offer a variety of methods to deliver desired substances to animal models with the option to simultaneously measure respiratory endpoints. Be certain all subjects breathe in a consistent amount with our inhalation tower and the Accumulated Inhaled Aerosol (AIA) parameter, exclusively available in Buxco FinePointe software.

Explore more about the key benefits of DSI’s Buxco Inhalation Exposure systems or read the below brochures.

 

 

The Ultimate Solution for Coronavirus Research
AIA Tech Note






head out plethysmography, respiratory, pleth  whole body plethysmography, pleth, wbp

M11_TRANS

Disease Progression and Treatment Evaluation
Respiratory Solutions
Collect direct or indirect respiratory measurements with our Buxco line of respiratory solutions. Measure endpoints such as resistance, compliance, minute volume, tidal volume, and more.


Telemetry Solutions
 Collect continuous, chronic physiologic data from conscious, freely moving animals and generate translatable results. Available endpoints and biomarkers include temperature, heart rate, heart rate variability, and more. DSI has telemetry installations at numerous U.S. Military, Government, Contract Research Organizations (CRO), and Academic labs. Many of these labs are using DSI systems in BSL-3 or -4 environments. Check them out!









Ponemah Acquisition







Data Acquisition and Analysis
Ponemah Software
 Your data is one of the most important assets and its management will have a huge impact on your success. Be certain of your data integrity using Ponemah software as your data engine in both GLP and non-GLP laboratory environments.
  • Data analysis using validated algorithms trusted by researchers to reliably obtain accurate, consistent results
  • Summarize and present your results based on the unique requirements of your study
Remote Notification
Avoid unnecessary entrance into BSL environments to check on your studies. Set convenient, automated alerts for subject-level and system-level conditions. Continuous physiologic monitoring should not need your undivided attention.  Remote Notification saves you time and provides peace of mind by monitoring subject health and system functionality, notifying you when necessary.

Data Insights
Stop wasting time manually scouring data. With Data Insights, execute automated, customizable searches to expose patterns and anomalies in your data. Advantageous when validating analysis performance, building ECG PRO template libraries, discerning treatment effect, screening for arrhythmia, and more.






Interested in seeing how others are using our solutions? Check out this sample of infectious disease publications.

Milechin, L., Davis, S., Patel, T., Hernandez, M., Ciccarelli, G., Schwartz, S., Hensley, L., Goff, A., Trefry, J., Cabrera, C., Fleischman, J., Reuther, A., Rossi, F., Honko, A., Pratt, W., & Swiston, A. (2017). Detecting pathogen exposure during the non-symptomatic incubation period using physiological data. BioRxiv. https://doi.org/10.1101/218818

Sheahan, TP., Sims, AC., Graham, RL., Menachery, VD., Gralinski, LE., Case, JB., Leist, SR., Pyrc, K., Feng JY., Trantcheva, I., Bannister, R., Park Y., Babusis, D., Clarke, MO., Mackman, RL., Spahn, JE., Palmiotti, CA., Siegel, D., Ray, AS., Cihlar, T., Jordan, R., Denison, MR., & Baric, RS. (2017). Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science Translational Medicine, 9(396). http://dx.doi.org/10.1126/scitranslmed.aal3653

Sheahan, TP., Sims, AC., Leist, Sr., Schäfer, A., Won, J., Brown, AJ., Montgomery, SA., Hogg, A., Babusis, D., Clarke, MO., Spahn, JE., Bauer, L., Sellers, S., Porter, D., Feng, JY., Cihlar, T., Jordan, R., Denison, MR., & Baric, RS. (2020). Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nature Communications, 11, 222. https://doi.org/10.1038/s41467-019-13940-6

Wonderlich, ER., Swan, ZD., Bissel, SJ., Hartman, AL., Carney, JP., O’Malley, KJ., Obadan, AO., Santos, J., Walker, R., Sturgeon, TJ., Frye Jr., LJ, Maiello, P., Scanga, CA., Bowling, JD., Bouwer, AL., Duangkhae, PA., Wiley, CA., Flynn, JL., Wang, J., Cole, KS., Perez, DR, Reed, DS., & Barratt-Boyes, SM. (2017). Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques. The Journal of Immunology, 198(4). https://doi.org/10.4049/jimmunol.1601770

Visit Google Scholar for additional publications.