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Buxco® Whole Body Plethysmography

 
The gold standard for indirect respiratory measurements in conscious, freely moving subjects

Benefits of whole body plethysmography explained in two minutes!




Whole Body Plethysmography Chambers

All Buxco WBP Chambers are made with a patented Halcyon® pneumotach noise suppression design and an integrated bias flow ports to ensure proper fresh air exchange. Explore additional details about each chamber size below.

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Buxco Small Animal WBP Chamber Details

  • View Mouse Pup WBP Chamber

  • View Small Animal WBP Chambers


Available Chambers (all types)






Mouse 4 site WBP 020
     

Buxco WBP Pro

Minimize Stress, Produce Critical Results

Buxco WBP Pro was released in 2012 and quickly became a new standard in the industry, utilizing a single control station that continuously communicates with FinePointe software to automate and regulate customer defined protocols.  With the inclusion of single-click automated calibration and diagnostics, the user experience has been greatly eased and improved, virtually removing human error while cleaning up data signals in the ultra-sensitive WBP environment to produce unparallel data collection environment.  
  • Improve animal welfare by reducing handling or restraint of subjects
  • Conduct high quality, reproducible experiments in subjects ranging in size from mouse pup (P3 and older) to canine and primate
  • Reduce the risk of human error with automated diagnostics and calibration
  • Trust your results with solutions featured in over 2,000 research publications 








Combined Applications

 

Buxco small animal WBP chambers can be combined with other technologies to enable more data and holistic approaches to every study including:
  • Optogenetics - Neural control of breathing
  • Electrical Commutator - Collect hardwired biopotential (EEG, EMG, EOG) signals simultaneously
  • Fluid Swivel - Administer compound, manage pain, draw blood, or create an injury model

Mouse WBP Optogenetics_chamber only_LR

soho biopotential

Respiratory + Implantable Telemetry

Combine Buxco WBP with implantable telemetry to investigate the link between cardiovascular or neurological function and respiratory function in studies on cardiovascular interactions, sleep apnea, neural control of breathing, and stress or anxiety.

Metabolism

Continuously monitor respiratory gasses from laboratory animals and compare oxygen and carbon dioxide levels to a reference. Leveraging Buxco WBP Pro's gas automation feature, hypoxia studies can easily be automated through software protocols. The Panlab gas analyzer fully integrates with the Buxco WBP Pro controller creating a turnkey solution.

buxco metabolism software 1
buxco metabolism software 2




Lungs

Multiple Applications and Derived Parameters With One System


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    WBP Derived Parameters

    • View List of WBP Derived Parameters

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    Apnea-Specific Derived Parameters

    • View List of Apnea Derived Parameters





    Applications & References

    Select publications citing small animal Buxco whole body plethysmography

    Bosnjak B, Tilp C, Tomsic C, Dekan G, Pieper M, Erb K, EpsteinM. “Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.” Pulmonary Pharmacology and Therapeutics. 2014;27:44-51.

    Glynn A, Alves D, Frick O, Erwin-Cohen R, Porter A, Norris S, Waag D, Nalca A. “Comparison of experimental respiratory tularemia in threenonhuman primate species.” Comparative Immunology, Microbiology and Infectious Diseases. 2015;39:13-24

    Haapakoski R, Karisola P, Fyhrquist N, Savinko T, Wolff H, Turjanmaa K, Palosuo T, Reunala T, Lauerma A, Alenius H. “Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-gamma-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.” American journal of respiratory cellular and molecular biology. 2011;44:639-647.

    Rajavelu P, Chen G, Xu Y, Kitzmiller J, Korfhagen T, Whitsett J. “Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation.” Journal of Clinical Investigation. 2015.

    Viby N, Isidor M, Buggeskov K, Poulsen S, Hansen J, Kissow K. “Glucagon-Like Peptide-1 (GLP-1) Reduces Mortality and Improves Lung Function in a Model of Experimental Obstructive Lung Disease in Female Mice.” Endocrinology. 2013;154:4503–4511.



    Select publications citing large animal Buxco whole body plethysmography

    Katalan S, Falach R, Rosner A, Goldvaser M, Brosh-Nissimov T, Dvir A, Mizrachi A, Goren O, Cohen B, Gal Y, Sapoznikov A, Ehrlich S, Sabo T, Kronman C. “A novel swine model of ricin-induced acute respiratory distress syndrome.” Disease Models & Mechanisms. 2017; 10(2): 173-183.

    Lin C, Wu H, Lee J, Liu C. “Functional Phenotype and its Correlation with Therapeutic Response and Inflammatory Type of Bronchoalveolar Lavage Fluid in Feline Lower Airway Disease.” J Vet Inter Med. 2015;29:88-96.

    Valente A, Silvestre A, Guasch L, Tort A, Marco I, Lavin S, Cuenca R. “Evaluation of pulmonary function in European land tortoises using whole-body plethysmography.” Veterinary Record. 2012;141:154.

    Guasch L, Vadillo A, Grau J, Carreton E, Morchon R, Simon F, Alonso J. “Evaluation of pulmonary function variables by using plethysmography in cats with respiratory disease associated to Dirofilaria immitis.: Veterinary Parasitology. 2012;187:254-258.

    Bernaerts F, Talavera J, Leemans J, Hamaide A, Claeys S, Kirschvink N, Clercx C. “Description of original endoscopic findings and respiratory functional assessment using barometric whole-body plethysmography in dogs suffering from brachycephalic airway obstruction syndrome.” The Veterinary Journal. 2010;183:95-102.



    2140
     Whole body plethysmography articles citing DSI in Google Scholar
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