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Drug Discovery Research

Accelerate your drug discovery timeline with comprehensive, integrated in vivo data collection

 

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DSI solutions provide drug discovery researchers with comprehensive data collection of vital in vivo parameters, enhancing data quality and reliability, particularly using Ponemah software. These solutions improve animal welfare by utilizing telemetry and hardwired systems, reducing the stress on test subjects. By accelerating the drug discovery timeline, researchers can rule out ineffective compounds earlier, focus on promising candidates, and bring successful drugs to market faster, resulting in major cost savings. Additionally, Ponemah's translational capabilities support compound advancement through safety and toxicology phases, providing a consistent platform throughout preclinical testing.

With over 40 years of experience serving discovery groups, DSI offers a flexible and versatile system that can be tailored to varying levels of complexity to meet researchers' specific needs



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Drug Discovery Solutions

 





Serving researchers from drug discovery through preclinical studies

With Ponemah, you can bring all data into a single platform, removing the need to manage disparate systems.

Serving researchers from basic through toxicology applications, Ponemah makes it easier to translate data as your candidate moves through the pipeline.

The Ponemah 5.x server-based system streamlines data collection and analysis, connecting all team members to reduce the need for exporting and sending data, and thus simplifying the entire discovery, safety, and toxicology workflow. Where needed, the software is SEND and GLP compliant, ensuring secure and compliant data collection when you're ready for FDA submission. 


Why do more researchers choose Ponemah?   

  • Easy study management
  • Versatile and robust acquisition interfaces
  • Accurate and consistent results using automated analysis
  • Advanced GLP compliance with Study Protocol and Data Security Features
  • Smart tools and modules to customize to your study-specific needs
  • And more!



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Ponemah Integrated Solutions





Acute Recordings



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Acute endpoints are critical for understanding a drug's immediate effects on an organism, such as mechanism of action, efficacy, and safety profile. Ponemah collects high quality acute functional endpoints for precise and controlled measurements of physiological parameters.






Acute Respiratory


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Plethysmography is a valuable tool used in drug discovery for assessing respiratory function in animal models. Collect respiratory data in Ponemah with Buxco Plethysmography chambers to assess the effects of drug candidates on the respiratory system and identify potential safety liabilities. 











Telemetry




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Telemetry stands as a cornerstone technology in modern drug discovery, providing unparalleled insights into the physiological responses of animal models to drug treatments. By enabling continuous monitoring of vital parameters, early detection of adverse events, optimization of drug dosing, elucidation of drug mechanisms of action, and longitudinal studies in chronic disease models, telemetry contributes to the development of safer and more effective therapies while enhancing animal welfare and clinical translation.

Learn more about Implantable Telemetry solutions
Learn more about External Telemetry solutions





Behavioral Assessment

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Our comprehensive suite of behavioral products delivers high-throughput assessment of cognitive and generalized activity, offering vital insights for drug discovery researchers. By accurately measuring behavior, these tools enable the identification of potential drug effects on cognition and overall activity levels. This facilitates the development of more effective treatments and accelerates the discovery process, ultimately leading to improved therapeutic outcomes for various neurological and psychiatric conditions.











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Isolated Organ

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Hugo Sachs' isolated organ solutions integrate seamlessly with DSI's Ponemah software, providing precise data collection and analysis for organ function studies. This integration allows drug discovery researchers to monitor real-time physiological responses, enhancing the accuracy of preclinical assessments. The combined system streamlines research workflows, improves data reliability, and accelerates the identification of promising drug candidates, ultimately leading to more effective and targeted therapies.









 

 


DSI Buxco FinePointe Solutions


Drug discovery researchers use a resistance and compliance respiratory system to simulate human lung mechanics in preclinical studies. This system assesses the impact of potential drugs on respiratory function by measuring airflow resistance and lung compliance. Accurate modeling of respiratory conditions aids in evaluating drug efficacy and safety, leading to better treatments for respiratory diseases and improved patient outcomes.
Non-invasive airway mechanics (NAM) respiratory systems enable drug discovery researchers to evaluate respiratory function in live subjects without surgical intervention. This system measures parameters like airway resistance and lung compliance, providing crucial data on the effects of new drugs. Its non-invasive nature ensures animal welfare while delivering accurate, reproducible results, aiding in the development of effective respiratory therapies.
Inhalation exposure systems are commonly used to administer aerosolized drugs to study subjects, mimicking real-world inhalation conditions. This system allows precise control of dosage and exposure duration, enabling the assessment of drug efficacy and safety in treating respiratory diseases. It ensures consistent delivery and accurate measurement of therapeutic outcomes, accelerating the development of inhalable treatments.





Additional Drug Discovery Solutions from Harvard Bioscience

  


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Micro Electrode Array

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Microelectrode arrays have revolutionized drug discovery, particularly in neuroscience and cardiology. These in vitro tools enable high-throughput assessment of a compound's electrophysiological effects on cellular networks and organoids. MEAs accelerate drug development by facilitating rapid screening of compound libraries, evaluating drug efficacy and toxicity, studying ion channel modulation, modeling neurodegenerative diseases, and assessing cardiac safety – all within a physiologically relevant network environment.


  

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Microdialysis

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Drug discovery researchers use microdialysis to sample extracellular fluid in tissues, measuring neurotransmitter levels and drug concentrations in real time. This technique provides insights into the pharmacokinetics and pharmacodynamics of new drugs, helping to understand their effects on the brain and other tissues. Microdialysis aids in evaluating drug efficacy, safety, and mechanisms of action, crucial for developing effective treatments for various diseases.


  
  

  
  

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Spectrophotometers



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Leveraging spectrophotometers, drug discovery researchers can measure the absorption and emission of light in samples, to determine the concentration of compounds. This technique is vital for analyzing drug purity, quantifying biomolecules, and monitoring reaction kinetics. Spectrophotometry enables precise, high-throughput screening of potential drugs, facilitating the identification and optimization of effective therapeutic agents.

  
  

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Syringe Pumps

  

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Drug discovery researchers use syringe pumps for precise and controlled delivery of liquids, including drugs and reagents, during experiments. These pumps ensure accurate dosing and flow rates, crucial for pharmacological studies, cell cultures, and in vivo testing. By maintaining consistent and reproducible administration, syringe pumps enhance experimental reliability and support the development of effective, safe therapeutics.