DSI Monitor - Winter 2016 (Issue 4)

• How will lower systolic blood pressure guidelines in humans affect preclinical research practices?

  Our latest PhysioBlog post describes how direct measurement in preclinical settings detects subtle shifts in blood pressure.
  
  
  
  

• Selecting non-human primates for research on aerosolized pathogens

  Inhaled pathogens are a serious bioterrorism threat, and developing therapeutics requires that preclinical researchers further explore how such pathogens manifest in animal models. This Physioblog post highlights a study focused on selecting the most appropriate non-human primate models for evaluating Rift Valley Fever Virus, a potential aerosolized bioterrorism agent.

• Tips and Tricks from Scientific Services

  Simplify ECG Analysis. Electrocardiogram (ECG) waveform analysis can be time-consuming and complex. Accurate and consistent placement of fiducial marks, including the P, Q, S and T waves, is required for reliable ECG waveform analysis. DSI’s Ponemah software and Data Services team provide several options that can help simplify ECG waveform analysis, while helping researchers extract more ­­­meaningful information and save time. 

  • Data Insights is Ponemah’s latest tool for optimizing ECG analysis. With Data Insights, execute customized searches to locate arrhythmias, data patterns, and anomalies. Data Insights helps researchers reduce time analyzing ECG waveforms while delivering greater analysis capability.
  • DSI’s Data Services team is available to analyze, summarize and report on your experimental data. Reducing time spent on data analysis and reporting processes allows you more time to evaluate the experimental results. 

  Contact us today with questions about ECG waveform analysis with Data Insights.
  
  
  

  
  
  
  
  
  
  
  
  
  
  
  
  
  See our new online tools! Gain answers to your Data Analysis and Validation questions quickly.

• Technical Note Spotlight

  We are pleased to provide you with a list of recommended surgical supplies for small animal surgeries. This is a helpful resource for new users or anyone who needs to make a few additions. 

• Ask DSI Tech Support

  Q: “I’m setting up a new telemetry system for measuring continuous glucose with the HD-XG, should I use continuous sampling or scheduled sampling to collect data?”
  
  A: There are several nuances to glucose telemetry that are different from the way telemetry is used in cardiovascular or neurological studies. Scheduled sampling provides significant advantages in prolonged experiments where battery life, transmitter re-use and data management are issues of concern. In the case of the HD-XG glucose implant the battery life is intended to outlast the viability of the glucose sensor. Also the implant is not intended for re-use, and since the HD-XG device has a lower sample rate, the file size for continuous sampling is of little concern. 

  Although one might think the scheduled sampling option would be ideal for a slowly changing parameter like blood glucose, scheduled sampling is actually detrimental to the accuracy of the transmitter calibration process. The in vivo calibration for the HD-XG implant involves taking live blood samples during a glucose tolerance test and comparing the glucose values measured with a glucometer to the output of the telemetry implant in real time. If the software schedule is between sampling periods when blood is drawn, the resolution of the calibration can be dramatically reduced. To maximize the accuracy of the HD-XG telemetry transmitter our recommendation is to turn the implant on prior to implantation, collect data using continuous sampling, and leave the transmitter on for entire duration of the experiment. 

  See our glucose microsite for more information on continuous glucose telemetry.

• DSI Social Housing Solutions

  DSI offers social housing solutions for research studies involving animals from mice to non-human primates.  
  

  • NEW! HD-S11 – Now available in two frequencies, this small animal implant is designed to support pair housing while measuring cardiovascular endpoints

  • NEW! Anipill – Monitor temperature in socially housed animals (currently available in US and EU)

  • 4ET – Pair housing implant for small animal CNS studies 

  • PhysioTel™ Digital – Social housing solution for acute or chronic large animal studies

  
  

• Early Praise for Data Insights

  "Data Insights has provided a major advancement for the ability to identify and quantify arrhythmias in large animal telemetry studies. Using this technology I was able to efficiently analyze 24-hour telemetry datasets in a 40 animal study in a time- and cost-effective manner."

  
  -Sr. Research Investigator, Biopharma company

• Product Transitions

  DSI is committed to providing the life science industry with reliable and innovative products with unsurpassed service. Long-term product availability is dependent upon many conditions, some of which are out of DSI’s control. It is our commitment that when the discontinuation of a product occurs, that it is done with the absolute minimum disruption and impact to our customers.

  Upon discontinuation a product can longer be ordered from DSI. DSI will notify customers and where possible, manage a last time purchase of the product. We will also recommend functional product equivalents as appropriate.

  The following products are currently being transitioned to new technologies:

  Implant Model	Replacement Model	Discontinuation Date
  PA-C40	PhysioTel™ HD-S10	December 31, 2016
  D70-PCT	PhysioTel Digital L11 or M11	December 31, 2016
  D70-PCTP	PhysioTel Digital L21	December 31, 2016
  D70-CCTP*	PhysioTel Digital L11 or M11	December 31, 2016
  PA-D70	PhysioTel Digital M10	December 31, 2016
  CTA-D70	PhysioTel Digital M01	December 31, 2106
  TA-D70	PhysioTel Digital M00	December 31, 2106

  *The D70-CCTP does not have a direct replacement as PhysioTel Digital does not have an implant with two biopotential channels.

  Note: PhysioTel Digital is only available for sale in North America and Europe; as such the discontinuation dates listed above do not apply to countries outside of these regions.

  DSI is transitioning to new products to take advantage of technology improvements as well as due to regulatory requirements.

  DSI’s newest telemetry platforms, PhysioTel™ HD and PhysioTel Digital, leverage the latest technological advancements to offer scientists the ability to:

  • collect more physiological signals per study
  • see improved pressure sensing and reduced drift
  • experience greater biopotential channel filtering
  • integrate social housing capabilities

  In an effort to improve the health of our environment, the European Union introduced the Restriction of the Use of Certain Hazardous Substances (RoHS) Directive in 2002. The objective behind RoHS is to eliminate harmful substances which are commonly found in electronic equipment.

  DSI is contributing to a healthier environment by using the cleanest processes and reducing the use of hazardous materials. This initiative also benefits DSI customers as they will have access to the latest, environmentally-friendly physiologic monitoring products available through DSI.

  Additional information regarding product discontinuation is available our website.

  • Product Discontinuation
  • Restriction of the Use of Certain Hazardous Substances (RoHS)
  • Software Support Lifecycle

• Glucose News

  We're not the only ones who think continuous glucose telemetry is amazing.The HD-XG won an Innovation Award from The Analytical Scientist magazine!
  
  DSI will be exhibiting at both ENDO (Booth 1236) and EB (Booth 1216) the first week of April. Come visit us to see the HD-XG in person and discuss your application.
  
  

  Check out the recorded webinar “Continuous Glucose Monitoring for Diabetes, Obesity and Metabolism Research in Rodents” featuring Dr. Ralf Dechend and Dr. Christian Schnell showcasing the use of HD-XG.
  
  

  
  
  

  Will continuous glucose monitoring enhance science and animal welfare? Partner with NC3Rs and DSI to prove and share the value of continuous glucose monitoring. Learn more here.
  

   

  See our glucose testimonials to learn how researchers are using continuous glucose monitoring to advance their research.

• Upcoming Events

  Scientific Meetings

  Attending any of these upcoming meetings? Stop by and visit DSI!

  Feb. 8-10: ASM Biodefense and Emerging Diseases Meeting - DSI booth 29

  March 13-17: Society of Toxicology and ToxExpo - DSI booth 1344

  April 1-4: ENDO - DSI booth 1236

  April 2-6: Experimental Biology - DSI booth 1216 

  See our full list of scheduled events here.

• Consider Including DSI in your NIH Grant Application

  NIH deadlines are fast approaching for new, renewal, re-submission and revision grant applications. If you are currently considering how to best invest in your research, we invite you to consider DSI as your partner for physiologic monitoring. We offer telemetry, instrumentation, software and services that help scientists advance their research.

  To learn more about our solutions or to request a quote, please contact us today.

• Our Website has a New Look!

  Check out our redesigned website, now optimized for use on mobile devices.