Sensorimotor and Coordination





Sensorimotor function encompasses a broad category of neurological processes driving motor control/coordination, vestibular function (balance), proprioception (positional awareness), as well as sensory-motor gating. Capturing motor abnormalities is not only key in study of related disease states but is important to consider as a convoluting factor when scoring performance in tests of emotion and cognition. Motor phenotyping is therefore an important starting point for many rodent model studies.

Rotorod







Common Applications

  • Ataxia
  • Brain Injuries
  • Cachexia
  • Parkinson's Disease
  • Neurodegenerative Diseases

  • Myopathies
  • Stroke/Ischemia
  • Huntington's Disease
  • Safety Pharmacology







 



Recent References

Rotameter (Rotational Behavior)
1. Radlicka A, Kamińska K, Borczyk M. et al. J. Effects of L-DOPA on Gene Expression in the Frontal Cortex of Rats with Unilateral Lesions of Midbrain Dopaminergic Neurons. eNeuro. 2021 Jan 21;8(1):ENEURO.0234-20.2020.

Startle (Sensory Motor Gating)
2. Watanabe M, Ferré S, Fernández-Dueñas V. et al. Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia. Neuropsychopharmacology. 2021 Feb;46(3):665-672.

3. Cano JC, Huang W, Fénelon K. The amygdala modulates prepulse inhibition of the auditory startle reflex through excitatory inputs to the caudal pontine reticular nucleus. BMC Biol. 2021 Jun 3;19(1):116.

4. Valle-León M, Callado LF, Aso E. et al. Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia. Neuropsychopharmacology. 2021 Feb;46(3):665-672.

Grip Strength (Muscular Strength)
5. Busquets S, Castillejo M, Jové Q. et al. Lack of Synergy Between β-Agonist Treatment and a Blockage of Sarcoplasmic Calcium Flow in a Rat Cancer Cachexia Model. Onco Targets Ther. 2021 Mar 17;14:1953-1959.

6. Park SH, Oh J, Jo M. et al. Water Extract of Lotus Leaf Alleviates Dexamethasone-Induced Muscle Atrophy via Regulating Protein Metabolism-Related Pathways in Mice. Molecules. 2020 Oct 9;25(20):4592.

7. Chen J, Li X, Xu S. et al. Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities. Front Cell Neurosci. 2020 Apr 3;14:77.

Rotarod (Motor Coordination)
8. Duarte-Neves J, Cavadas C, Pereira de Almeida L. Neuropeptide Y (NPY) intranasal delivery alleviates Machado-Joseph disease. Sci Rep. 2021 Feb 8;11(1):3345.

9. Ramis MR, Sarubbo F, Moranta D. et al. Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechin in Aged Rats. Antioxidants (Basel). 2021 Apr 19;10(4):621.

10. Martinisi A, Flach M, Sprenger F. et al. Severe oligomeric tau toxicity can be reversed without long-term sequelae. Brain. 2021 Apr 12;144(3):963-974.